Microdosing TRT Through a Circadian Lens

A Physiology-First Approach to Hormone Replacement By Chris Duffin Most TRT protocols are still built around pharmacokinetics. Half-life charts. Ester duration. Serum stability. What they are not built around is human biology. Testosterone is not meant to be continuously elevated. It is meant to follow a daily rhythm. When delivery ignores that rhythm, downstream systems […]

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